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罗霞
发布时间:2019-06-23      来源:       点击:

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罗霞

学位: 博士          职称: 副研究员

教育、工作经历

2020/01-至今    77779193永利官网    77779193永利官网    副研究员
2018/01-2019/12 77779193永利官网   77779193永利官网    高级实验师
2013/01-2017/12  77779193永利官网   77779193永利官网    实验师
2009/07-2012/12  77779193永利官网   临床药理所  研究实习员
2014/09-2017/06 77779193永利官网 中西医结合基础  博士 导师:周联
2006/09-2009/06 77779193永利官网 中西医结合基础  硕士 导师:周联
2001/09-2006/06 甘肃中医药大学 针灸推拿学      学士 导师:慕宝龙

研究方向

1)中药抗炎免疫药理;2)黏膜免疫

科研及教学课题

                   1.国家自然科学基金,81703785,黄芩汤修复微生物屏障及抑制MDP-NOD2炎症信号通路治疗炎症性肠病,2018.01-2020.12,在研,20万元,主持
2.77779193永利官网青年英才项目,靶向芳香烃受体激活IL-22/STAT3信号通路在清热止痢复方修复肠上皮治疗肠炎中的作用,2019/11-2023/11,20万元,在研,主持
3.广东省普通高校特色创新项目,2020KTSCX026, 黄芩素通过激活ILC3-AhR/IL-22通路修复肠上皮治疗溃疡性结肠炎,2020.06-2022.06,在研,10万元,主持
4.广东省普通高校特色创新项目,2017KTSCX042, 大黄素激活 PPARγ信号产生三重效应发挥治疗IBD的作用,2018.01-2019.12,已结题,10万元,主持
5.广东省自然科学基金自由申请,2015A030313344,从肠道菌群调控Th17/Treg探讨大黄牡丹汤治疗IBD的机制,2015.08-2018.08,10万元,已结题,主持
6.广东省教育厅科研项目,2013LYM0014,肠道菌群作为四君子汤多糖改善脾虚小鼠免疫状态的作用靶点研究,2014.01-2015.12,3万元,已结题,主持
7.77779193永利官网优秀青年学者科研基金,四君子汤多糖对抗生素引起小鼠菌群失调及免疫损伤的保护机制研究,2013.03-2015.12,5万元,已结题,主持
8.国家自然科学基金,81673668,大黄牡丹汤通过短链脂肪酸抑制“鞭毛蛋白-TLR5炎症信号通路”治疗IBD的机制研究,2017.01-2020.12,60万元,已结题,参加
9.国家自然科学基,81603587,基于AnnexinA5-Nlrp3通路探讨三黄泻心汤对痰浊血淤型高脂血症内皮胞膜的调节作用,2017.01-2019.12,17万元,已结题,参加
10.国家自然科学基金,81373697,小青龙汤通过PKCδ/ERK/PARP-1信号通路调节H1R表达治疗变应性鼻炎的机制研究,2014.01-2017.12,86万元,已结题,参加
11. 广东省专业类在线开放课程:《中药药理学》,2019.02—2020.12,15万元,参与。
12. 77779193永利官网虚拟仿真实验教学项目:麻黄碱的平喘作用,2019.12—2020.12,10万元,参与。
13. 77779193永利官网在线开放课程:《中药药理学》,2020.01—2020.12,10万元,参与。

 

承担的课程

主要承担《中药药理学》、《药理学》、《免疫学》、《抗体工程药物》等课程。

专著

中西医结合实验技术与方法(编委),科学出版社,出版日期:2020.09,ISBN:978-7-03-065923-1。

代表性研究论文

  1. 1. Yan-yang Li, Xiao-jing Wang, Yu-lin Su, Qing Wang, Shao-wei Huang, Zeng-feng Pan, Yan-ping Chen, Jun-jie Liang, Mei-ling Zhang, Xue-qian Xie, Zhi-yun Wu, Jin-yan Chen, Lian Zhou*, Xia Luo*. Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s, Acta Pharmacologica Sinica, 2021, 2021(0): 1-13.

    2. Shaowei Huang#, Yajun Fu, Bo Xu, Chang Liu, Qing Wang, Shuang Luo, Feifei Nong, Xiaojing Wang, Songyu Huang, Jinyan Chen, Lian Zhou*, Xia Luo*. Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway. Phytomedicine. 2020; 68: 153179.

    3. Shaowei Huang, Jinrong He, Yanping Chen, Xiaojing Wang, Yanyang Li, Yulin Su, Ruyan Wen, Xiuling Li, Guanghua Yang, Shuang Luo, Zhou*, Xia Luo*. Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway, Pharmaceutical Biology, 2022, 60(1): 108-118.

    4. Xu Bo, Huang Shaowei, Chen Yanping, Wang Qing, Luo Shuang, Li Yanyang, Wang Xiaojing, Chen Jinyan, Luo Xia*, Zhou, Lian*. Synergistic effect of combined treatment with baicalin and emodin on DSS-induced colitis in mouse, Phytotherapy Research, 2021, 35(10): 5708-5719.

    5. Ya-Jun Fu, Bo Xu, Shao-Wei Huang,Xia Luo, Xiang-Liang Deng, Shuang Luo, Chang Liu, Qing Wang, Jin-Yan Chen, Lian Zhou. Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14 . Acta Pharmacol Sin, 2021, 42: 88-96.

    6. Liu Chang#, Li Yanyang#, Chen Yanping, Shaowei Huang, Xiaojing Wang, Shuang Luo, Yulin Su, Lian Zhou*, Xia Luo*. Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis. Mediators of Inflammation, 2020, 2020: 5918587.

    7.Xia Luo#, Xiaojing Wang, Shaowei Huang, Bo Xu, Shuang Luo, Yanyang Li, Qing Wang, Yanping Chen, Xiangliang Deng, Lingyun Liu, Lian Zhou. Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway. International immunopharmacology, 2020, 90.

    8.Luo, X#, Xu, B#., Xiong, T., Su, Y., Liu, C., Ye, Y., Ou, M., & Zhou, L*. Hepatic dysfunction induced by intestinal dysbacteriosis mainly manifests as immunologic abnormity in mice. Pathogens and disease, 2020, 78(6), ftaa041.

    9. Shuang Luo#, Ruyan Wen#, Qing Wang, Zhongxiang Zhao, Feifei Nong, Yajun Fu, Shaowei Huang, Jinyan Chen, Lian Zhou*, Xia Luo*. Rhubarb peony decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17/Treg balance. Journal of Ethnopharmacology, 2019,231:39-49.

    10.Xia Luo#, Zengfeng Pan#, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou*. Effects of ceftriaxone-induced intestinal dysbacteriosis on regulatory T cells validated by anaphylactic mice. International immunopharmacology, 2018, 60: 221-227.

    11.Xia Luo#, Shaowei Huang, Shuang Luo, Haifeng Liao, Yuanyuan Wang, Xiangliang Deng, Fangli Ma, Chung Wah Ma, Lian Zhou*. Identification of genes underlying the enhancement of immunity by a formula of lentinan, pachymaran and tremelia polysaccharides in immunosuppressive mice. Scientific reports, 2018, doi: 10.1038/s41598-018-28414-w.

    12. Shuang Luo#, Xiangliang Deng, Qi Liu , Zengfeng Pan, Zhongxiang Zhao, Lian Zhou*, Xia Luo*. Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice. International immunopharmacology, 2018, 59: 269-275.

    13.Xia Luo#,Yanyi Zheng,Ruyan Wen,Xiangliang Deng,Lian Zhou*,Haifeng Liao. Effects of ceftriaxone induced intestinal dysbacteriosis on lymphocytes in different tissues in mice. Immunobiology, 2016, 221(9): 994-1000.

    14. Qiu M#, Yang B, Cao D, Zhu J, Jin J, Chen Y, Zhou L, Luo X*, Zhao ZX*. Two new hydroxylated ent-kauranoic acids from Pteris semipinnata. Phytochemistry Letters, 2016, 16:156-162.

    15. Ji-Yan Su#, Xia Luo#, Xiao-Jun Zhang, Xiang-Liang Deng, Zi-Ren Su, Lian Zhou , Shan-Shan Li, Zhenhua Dai, Yang Xu, Xiao-Ping Lai*. Immunosuppressive activity of pogostone on T cells: Blocking proliferation via S phase arrest. International immunopharmacology, 2015, 26(2):328-337.

    16. Xiangliang Deng#, Shuang Luo, Xia Luo, Minghua Hu, Fangli Ma, Yuanyuan Wang, Xiaoping Lai, Lian Zhou*. Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice. Journal of Immunology Research, 2018, doi: 10.1155/2018/3431782.

    17. Zengfeng Pan#, Yuan Zhou, Xia Luo, Yan Ruan, Lian Zhou*, Qing Wang, Ya jie Yan, Qi Liu, Jinyan Chen. Against NF-κB/thymic stromal lymphopoietin signaling pathway, catechin alleviates the inflammation in allergic rhinitis [J]. International Immunopharmacology, 2018, 61: 241–248.

    18. Xiangliang Deng#, Xiangling Li, Shuang Luo, Yongyan Zheng, Xia Luo, Lian Zhou*. Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study [J]. Food & Nutrition Research, 2017, 61:1399770.

    19. Xianghua Guo#, Runhua Guo, Xia Luo, Lian Zhou*. Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses, International Immunopharmacology, 2015, 29(2): 454-461.

    20.罗霞#,罗爽,郑彦懿,温如燕,邓向亮,周联*. 肠道菌群失调增加小鼠肠上皮间T淋巴细胞活化和促炎细胞因子分泌. 细胞与分子免疫学杂志, 2016,32(8):1031-1035。

    21.罗霞#,马忠华,胡明华,马方励,温如燕,周联*. 复合多糖对小鼠细胞免疫功能的影响. 中国食品卫生杂志, 2016, 28(2): 186-191.


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