2015年博士毕业于中山大学，随后在中山大学“有害生物控制与资源利用国家重点实验室”从事博士后研究。2019年美国加州大学洛杉矶分校分子成像中心访问学者。2017年以“杏林青年学者”身份引进到77779193永利官网工作至今。

研究领域：中药抗炎结构药理学

研究方向：（1）中药药效分子作用靶点发现与确证；

                            （2）基于“成分-靶点”互作结构的抗炎机制解析。

1. 国家自然科学基金优秀青年科学基金项目，82322074， 2024/01-2026/12，200万元，主持，在研。

2. 77779193永利官网青年拔尖人才 (团队) 培育“揭榜挂帅”项目，2023/09-2026/09，50万元，主持，在研。

3. 国家自然科学基金面上项目，82274214，2023/01-2026/12，52万元，主持，在研。

4. 广东省教育厅重点领域项目，2022ZDZX2010，2023/01-2025/12，10万元，主持，在研。

5. 广州市基础与应用基础研究项目，202201011420，2022/04-2024/03，5万元，主持，在研。

6. 广东省教育厅，2019年广东省高等学校青年珠江学者，2019/10-2022/09, 100万，主持，结题。

7. 国家自然科学基金青年项目，31700625，2018/01-2020/12，24万元，主持，结题。

8. 广东省基础与应用基础面上项目，2017A030310190，2017/05-2020/5，10万元，主持，结题。

9. 中国博士后科学基金特别资助，2017T100654，2017/01-2017/06，15万元，主持，结题。

        本科生教学:《药理学》《药物毒理学》和《结构生物学与现代药学研究》；

        研究生教学:《药学专论》的蛋白质结构药理学部分。

1. Caiyan Wang^#(王彩艳，第一作者), Xiaojun Teng, Chuang Wang, Binjie Liu, Runze Zhou, Xueyu Xu, Huawei Qiu, Yu Fu, Rongjin Sun, Zuhui Liang, Rong Zhang, Zhongqiu Liu*, Lin Zhang*, Lijun Zhu*. Insight into the mechanism of Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS. Phytomedicine, 2023, 120:155040.

2. Huan Lan, Ying Zhang, Minqi Fan, Bingxin Wu, Caiyan Wang*(王彩艳，通讯作者). Pregnane X receptor as a therapeutic target for cholestatic liver injury. Drug metabolism reviews. 2023, 1-17.

3. Fang Wu, Yuanyuan Cheng, Jianfu Zhou, Xuehua Liu, Rongwu Lin, Songtao Xiang, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者).  Zn²⁺ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones. Int J Biol Macromol. 2023, 15;234:123320.

4. Zibo Li^#, Lin Jiang^#, Jiadong Ni, Yuanhang Xu, Fang Liu, Wenming Liu, Shaogui Wang*, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者). Salvianolic acid B Suppresses Hepatic Fibrosis by Targeting Ceramide Glucosyltransferase in Hepatic Stellate Cells. Acta Pharmacologica Sinica, 2023, 44(6):1191-1205.

5. Lin Zhang, Yuanhang Xu, Xuerong Zhang, Yibing Yang, Jiangyong Gu, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者). The Structural Basis of Conserved Residue Variant Effect on Enzyme Activity of UGT2B15, BBA - Proteins and Proteomic, 2023, 1871(3):140888.

6. Tian-Tian Wang^#, Li-Chun Zhang^#, Zhen Qin, Shu-Jun Chen , Jing-Min Zeng, Jing-Yan Li, Lin An, Cai-Yan Wang(王彩艳), Yong Gao, LiMing Wang, ZhongXiang Zhao*, ZhongQiu Liu*, Shao-Gui Wang*. Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation. Acta Pharmacol Sin. 2023, doi: 10.1038/s41401-023-01139-x.

7. Tao Su, Suchao Huang, Yanmin Zhang, Yajuan Guo, Shuwei Zhang, Jiaji Guan, Mingjing Meng, Linxin Liu, Caiyan Wang(王彩艳), Dihua Yu, Hiu-Yee Kwan, Zhiying Huang, Qiuju Huang, Elaine Lai-Han Leung, Ming Hu, Ying Wang, Zhongqiu Liu*, Linlin Lu*. miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis. Acta Pharm Sin B. 2022 ;12(2):821-837.

8. Juan Liu, Yuxin Zhuang, Jianlin Wu, Qiang Wu, Meixian Liu, Yue Zhao, Zhongqiu Liu, Caiyan Wang(王彩艳), Linlin Lu, Yingjiao Meng, Kawai Lei, Xiaojuan Li, Qibiao Wu, Elaine Lai-Han Leung, Zhengyang Guo, Liang Liu*, Ting Li*. IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα. Acta Pharm Sin B.  2022, 12(2):651-664.

9. Baoyuan Huang, Qiumei Wang, Lin Jiang, Shuru Lu, Chengcheng Li, Chunqi Xu, Caiyan Wang*(王彩艳，共同通讯作者), Enxin Zhang*, Xiaojun Zhang*. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Frontiers in Pharmacology, 2022, 17;13:926945.

10. Xuerong Zhang, Shehan Li, Zibo Li, Liangkai Cheng, Zhongqiu Liu, Caiyan Wang*(王彩艳，通讯作者). The therapeutic potential of targeting Hsp90-Cdc37 interactions in several diseases. Current Drug Targets, 2022. 23(10):1023-1038.

11. Lin Zhang, Wei Xie, Xiaojun Teng, Kui Wang, Wei Xie*, Caiyan Wang*(王彩艳，通讯作者). Improving the Extraction of Active Ingredients from Medicinal Plants by XynA Modification. Journal of Chemistry, 2022, doi:10.1155/2022/2483797.

12. Xuerong Zhang^#, Shehan Li^#, Zibo Li, Liangkai Cheng, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者). The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases. Current Drug Targets, 2022, 23(10):1023-1038.

13. Zibo Li, Lin Zhang, Dan Liu, Caiyan Wang*(王彩艳，通讯作者). Ceramide glycosylation and related enzymes in cancer signaling and therapy. Biomedicine & Pharmacotherapy, 2021, 139:111565.

14. Yuanyuan Cheng^#, Liangkai Cheng^#, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang*(王彩艳，共同通讯作者), Zhongqiu Liu*. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics, 2021; 11(2): 861-877.

15. Dan Liu，Qi Yu，Zibo Li，Lin Zhang，Ming Hu，Caiyan Wang*(王彩艳，共同通讯作者)，Zhongqiu Liu*, UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder, Biochemical Pharmacology, 2021, 190:114592.

16. Liangkai Cheng, Huihui Wang, Shehan Li, Zhongqiu Liu, Caiyan Wang*(王彩艳，通讯作者). New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations, Life Sciences, 2021, 282:119791.

17. Wei Xie, Qi Yu, Ruiqing Zhang, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Zhongqiu Liu, Kui Wang*, Caiyan Wang*(王彩艳，通讯作者). Insights into the Catalytic Mechanism of a Novel XynA and Structure-Based Engineering for Improving Bifunctional Activities. Biochemistry，2021, 60(26):2071-2083.

18. Ying Zhang, Caiyan Wang*(王彩艳，通讯作者). Demethyltransferase AlkBH1 Substrate Diversity and Relationship to Human Diseases. Molecular Biology Reports, 2021, 48(5):4747-4756.

19. Wei Liu^#, Yanxiang Cui^#, Caiyan Wang (王彩艳), Zihang Li, Danyang Gong, Xinghong Dai, Guo-Qiang Bi, Ren Sun, Z Hong Zhou*. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus. Nature Microbiology, 2020, 5(10):1285-1298.

20. Liangkai Cheng, Hong Zhang, Fang Wu, Zhongqiu Liu, Yuanyuan Cheng*, Caiyan Wang*(王彩艳，通讯作者). Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity. 2020, 4683943.

21. Lin Zhang^#, Lijun Zhu^#, Wei Qu, Fang Wu, Ming Hu, Wei Xei*, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者). Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochemical Pharmacology, 2020, 172:113753.

22. Hong Li, Ying Zhang, Yajuan Guo, Rong Liu, Qi Yu, Lingzhi Gong, Zhongqiu Liu*, Wei Xie*, Caiyan Wang*(王彩艳，通讯作者). ALKBH1 Promotes Lung Cancer by Regulating m6A RNA Demethylation. Biochemical Pharmacology, 2020, 114284.

23. Qi Yu, Zonglang Liao, Dan Liu, Wei Xie, Zhongqiu Liu, Guochao Liao*, Caiyan Wang*(王彩艳，通讯作者). Small molecule inhibitors of the prostate cancer target KMT2D. Biochemical and Biophysical Research Communications, 2020, 10;533(3):540-547.

24. Dan Liu, Lin Zhang, Lixin Duan, Jinjun Wu, Ming Hu, Zhongqiu Liu*, Caiyan Wang*(王彩艳，通讯作者). Potential of Herb-Drug/Herb Interactions between Substrates and Inhibitors of UGTs Derived from Herbal Medicines. Pharmacological Research, 2019, 150:104510.

25. Fang Wu, Liangkai Cheng, Qi Yu, Lin Zhang, Hong Li, Caiyan Wang*(王彩艳，通讯作者). Purification and functional characterization of the C-terminal domain of the β-actin-binding protein AIM1 in vitro, Molecules. 2018, 23(12): 3281.

26. Caiyan Wang^#(王彩艳，第一作者), Qian Jia^#, Jianhua Zeng, Ran Chen, Wei Xie*. Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Science Advances, 2017, 3(12):1-9.

27. Caiyan Wang(王彩艳，第一作者), Jianhua Zeng, Wei Xie*, A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1. FEBS Letters, 2017, 591(2):433-441.

28. Caiyan Wang^#(王彩艳，第一作者), Qian Jia ^#, Ran Chen, Yuming Wei, Juntao Li, Jie Ma, Wei Xie*. Crystal structures of the bifunctional tRNA methyltransferase Trm5a. Scientific Reports, 2016, 6: 33553.

29. Caiyan Wang(王彩艳，第一作者), Yu Guo, Qingnan Tian, Qian Jia, Yuanzhu Gao, Qinfen Zhang, Chun Zhou, Wei Xie*. SerRS-tRNA^Sec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Research, 2015, 43(21): 10534-10545.